The evolution of antibiotic resistance | Science-- &#; Additionally, the dominant enteric pathogens Escherichia coli and Klebsiella pneumoniae have evolved resistance to the most recent generation of β-lactam antibiotics by acquiring plasmids carrying extended-spectrum β-lactamases and carbapenemases ( : R. Craig MacLean, Alvaro San Millan
The Evolution of Antibiotic Resistance - ScienceDirect-- &#; Antibiotic resistance refers to the property of bacteria which prevents the inhibition of their growth by antimicrobial agents used in the clinical setting. During the : Fernando Gonz&#;lez-Candelas, I&#;aki Comas, Jos&#; Luis Mart&#;nez, Juan Carlos Gal&#;n, Fernando Baquero
The evolution of antibiotic resistance: insight into the roles The evolution of antibiotic resistance is an amazingly simple example of adaptation by natural selection, and there is growing interest among evolutionary biologists in using : R Craig Maclean, Alex R Hall, Gabriel G Perron, Angus Buckling
The evolution of antibiotic resistance in a structured host The evolution of antibiotic resistance in opportunistic pathogens such as Streptococcus pneumoniae, Escherichia coli or Staphylococcus aureus is a major public health problem, : Fran&#;ois Blanquart, Sonja Lehtinen, Sonja Lehtinen, Marc Lipsitch, Christophe Fraser, Christophe Fra
Origins and evolution of antibiotic resistance - PubMedAbstract. Antibiotics have always been considered one of the wonder discoveries of the th century. This is true, but the real wonder is the rise of antibiotic resistance in hospitals, : Julian Davies, Dorothy Davies
Evolution of Antibiotic Resistance - Evolutionary Biology-- &#; The ecology and evolution of antibiotic-resistant bacteria. In Evolution in health and disease. Edited by S. C. Stearns and J. C. Koella, –. New York: Oxford Univ.
Mutation and evolution of antibiotic resistance: antibiotics Antibiotic resistance appearance and spread have been classically considered the result of a process of natural selection, directed by the use of antibiotics. Bacteria, that have to face
Inhibiting the Evolution of Antibiotic Resistance-- &#; Additionally, our evolution assays, which mimic the variable antibiotic concentrations seen during clinical infections, suggest that Mfd is required for developing
Analysis of the evolution of resistance to multiple -- &#; We used seven starting strains for laboratory evolution to observe a wide range of phenotypic changes associated with the evolution of antibiotic resistance . Six
[PDF]The Evolution of Antibiotic Resistance within Patients-- &#; .. Acquisition of resistance Antibiotic resistance can arise by the acquisition of resistance determinants from other organisms by horizontal gene transfer or by the
The Evolution of Antibiotic Resistance - ScienceDirect-- &#; Antibiotic resistance refers to the property of bacteria which prevents the inhibition of their growth by antimicrobial agents used in the clinical setting. During the past decade many research, editorial, and review articles have focused on antibiotic resistance ( Levy and Marshall, , Pitout and Laupland, , Livermore, ).
The evolution of antibiotic resistance | Semantic Scholar-- &#; Understanding how ABR evolves and spreads is key to improving antibiotic treatment strategies, and clinically relevant evolution studies are needed to help fight the spread of antibiotic resistance. Clinically relevant evolution studies are needed to help fight the spread of antibiotic resistance For most of human history, bacterial pathogens have
The evolution of antibiotic resistance | RARE Project - EuropaThe EU-funded RARE (Revealing antibiotic resistance evolution) initiative worked to find novel ways of using antibiotics more efficiently and stop or slow down evolution of antibiotic resistance. In this context, researchers set out to measure the evolutionary rate of resistance emergence under single and combinatorial drug treatments. The
Evolution of Antibiotic Resistance - Evolutionary Biology-- &#; The ecology and evolution of antibiotic-resistant bacteria. In Evolution in health and disease. Edited by S. C. Stearns and J. C. Koella, –. New York: Oxford Univ. Press. An overview of the antibiotic resistance problem within a framework based on ecological and evolutionary principles. Chadwick, D. J., and J. Goode, eds.
The evolution of plasmid-carried antibiotic resistance-- &#; The emergence of antibiotic resistance in pathogenic bacteria, both in hospital and community-acquired infections, represents a significant public health problem [ – ]. Bacterial cells are capable of transferring genes horizontally. This DNA transfer can take place in three ways, through plasmids, phages, or uptake of naked DNA [ ].
Integron activity accelerates the evolution of antibiotic -- &#; A genetic element known as an integron can help to manage that burden. This piece of genetic information is formed of a succession of ‘cassettes’ containing antibiotic resistance genes. More proteins are made from the genes present at the start of the integron, compared to the ones towards the end. When bacteria encounter antibiotics, an
Analysis of the evolution of resistance to multiple -- &#; We used seven starting strains for laboratory evolution to observe a wide range of phenotypic changes associated with the evolution of antibiotic resistance . Six out of the seven starting strains had drug-resistant phenotypes, obtained by laboratory evolution over approximately generations [ ].
Inhibition of Mutation and Combating the Evolution of -- &#; LexA Cleavage Is Required for the Evolution of Resistance to Ciprofloxacin and Rifampicin In Vivo. To test whether activation of the SOS response is required to induce the mutations that confer ciprofloxacin resistance during therapy, we used a neutropenic murine thigh infection model [] and the pathogenic E. coli strain ATCC .Mice were infected
The role of interspecies recombination in the evolution of -- &#; Multidrug-resistant Streptococcus pneumoniae emerge through the modification of core genome loci by interspecies homologous recombinations, and acquisition of gene cassettes. Both occurred in the otherwise contrasting histories of the antibiotic-resistant S. pneumoniae lineages PMEN and PMEN. A single PMEN clade spread globally,
An optimized antimicrobial peptide analog acts as an -- &#; The misuse of antibiotics in animal protein production has driven the emergence of a range of drug-resistant pathogens, which threaten existing public health security. Consequently, there is an
(PDF) The Evolution of Antibiotic Resistance - Academia.eduThe most classical mechanisms of intrinsic resistance are the absence of the tar- get and a reduced permeability to a given antibiotic. These two mechanisms are passive systems of resistance. However, bacterial populations also present active mechanisms of resistance based on the detoxification of the antibiotic.
The evolution of antibiotic resistance in a structured host The evolution of antibiotic resistance in opportunistic pathogens such as Streptococcus pneumoniae, Escherichia coli or Staphylococcus aureus is a major public health problem, as infection with resistant strains leads to prolonged hospital stay and increased risk of death. Here, we develop a new model of the evolution of antibiotic resistance in a commensal
The evolution of antibiotic resistance in a -- &#; The evolution of antibiotic resistance in opportunistic pathogens such as Streptococcus pneumoniae, Escherichia coli or Staphylococcus aureus is a major public health problem, as infection with resistant
Evolution of Antibiotic Resistance - Evolutionary Biology-- &#; The ecology and evolution of antibiotic-resistant bacteria. In Evolution in health and disease. Edited by S. C. Stearns and J. C. Koella, –. New York: Oxford Univ. Press. An overview of the antibiotic resistance problem within a framework based on ecological and evolutionary principles. Chadwick, D. J., and J. Goode, eds.
The evolution of antibiotic resistance - Biocidium Understanding how ABR evolves and spreads is key to improving antibiotic treatment strategies. Date: Sep , Source: Science Author: R. Craig MacLean, Alvaro San Millan Excerpt: “Two main approaches have been used to understand the processes driving the spread of ABR. Clinical studies have focused on DNA sequencing to identify the
The evolution of antibiotic susceptibility and resistance -- &#; Evolution could involve mutations that convey resistance to single antibiotics (specialized resistance) or to whole suites of antibiotics (broad-spectrum resistance ). The occurrence of variants resistant to antibiotics may provide an “insurance effect” [ , , ] by creating subpopulations of cells that can survive or even
The evolution of plasmid-carried antibiotic resistance-- &#; The emergence of antibiotic resistance in pathogenic bacteria, both in hospital and community-acquired infections, represents a significant public health problem [ – ]. Bacterial cells are capable of transferring genes horizontally. This DNA transfer can take place in three ways, through plasmids, phages, or uptake of naked DNA [ ].
The ecology and evolution of antibiotic-resistant bacteriaAssociations among resistance genes, and the process of compensatory evolution, can cause retention of resistance genes, even in the absence of selection favoring resistance. Novel approaches to antimicrobial therapy may provide alternatives to traditional broad-spectrum antibiotics for which resistance is less quick to evolve.
Chlorhexidine leads to the evolution of antibiotic-resistant -- &#; Antimicrobial resistance is a major public-health concern. We evaluate chlorhexidine role in selection of resistant Pseudomonas aeruginosa mutants and their antibiotic cross-resistance. Mutation frequency and mutation rate after short-term exposure to sub-inhibitory concentrations of chlorhexidine were compared to those after
Antibiotic resistance: delaying the inevitableUnnecessary use of antibiotics for agricultural and livestock purposes may lead to the evolution of resistant strains. Later, these strains will not be able to be controlled by antibiotics when it really is necessary. Preventive use of antibiotics on livestock and crops can also introduce antibiotics into the bodies of the humans who eat them.